Eccentricity about tease, wretched (6)
I believe the answer is:
tragic
'wretched' is the definition.
(thesaurus)
'eccentricity about tease' is the wordplay.
'eccentricity' becomes 'tic' (I've seen this in another clue).
'about' is an insertion indicator.
'tease' becomes 'rag' (synonyms).
'tic' going around 'rag' is 'TRAGIC'.
(Other definitions for tragic that I've seen before include "Causing extreme distress or sorrow" , "Grievous" , "'Very, very sad (6)'" , "Ill-fated" , "Pathetic" .)