Employer in old city around southeast (4)
I believe the answer is:
Here is my best explanation:
'employer' is the definition.
'old city around southeast' is the subsidiary indication.
'old city' becomes 'ur' (ancient city state).
'around' indicates putting letters inside.
'southeast' becomes 'se' ('SE' can be a synonym of 'southeast').
'ur' enclosing 'se' is 'user'.
'in' is the link.
(Other definitions for user that I've seen before include "Ruse (anag.)", "One who employs", "ruse", "Druggie", "Person employing something", "Ruse for employer", "Addict", "Right long-established", "Maybe one needing pot" and "Operator; exploiter".)