End of italics slanted and unnatural (7)
I believe the answer is:
stilted
'unnatural' is the definition.
('stilted' can be similar in meaning to 'unnatural')
'end of italics slanted' is the wordplay.
'end of' says to take the final letters.
'slanted' becomes 'tilted' ('tilt' can be a synonym of 'slant').
The final letter of 'italics' is 's'.
's'+'tilted'='STILTED'
'and' is the link.
(Other definitions for stilted that I've seen before include "Unnatural sounding and overformal" , "Stiff and pompous" , "Artificially formal or contrived" , "Stiff, self-conscious" , "Bombastic (of speech, writing)" .)