European film, major work (4)
I believe the answer is:
epic
'major work' is the definition.
(I've seen this before)
'european film' is the wordplay.
'european' becomes 'E' (abbreviation e.g. EU).
'film' becomes 'pic' (short for picture).
'e'+'pic'='EPIC'
(Other definitions for epic that I've seen before include "Heroic poem, film" , "Nonsense, rubbish" , "On a grand scale like long poem" , "Impressive scope" , "Long poem set in nice picture" .)