Family in street with no money (5)
I believe the answer is:
skint
'with no money' is the definition.
'family in street' is the wordplay.
'family' becomes 'kin' ('kin' can be a synonym of 'family').
'in' indicates putting letters inside.
'street' becomes 'st'.
'kin' inserted into 'st' is 'SKINT'.
(Other definitions for skint that I've seen before include "Broke (slang)" , "Having little money" , "Extremely poor" , "Hard up (sl.)" , "Stony-broke" .)