Fault that big-headed stupid male! (5)
I believe the answer is:
blame
'fault' is the definition.
(synonyms)
'big-headed stupid male' is the wordplay.
'big-headed' becomes 'b' (this could be a standard abbreviation I've not previously seen).
'stupid' indicates an anagram (in a stupid order).
'male' anagrammed gives 'lame'.
'b'+'lame'='BLAME'
'that' is the link.
Can you help me to learn more?
(Other definitions for blame that I've seen before include "Inculpate" , "Hold (a person) responsible" , "Impute fault to" , "Accountability" , "Attribute fault or guilt to" .)