Fired with rage (3)
I believe the answer is:
ire
'rage' is the definition.
(I've seen this before)
'fired with' is the wordplay.
'with' indicates a hidden word.
'IRE' is hidden within 'fired'.
(Other definitions for ire that I've seen before include "Losing head" , "Fury" , "Annoyance, vexation" , "'Anger, wrath (3)'" , "passionate feeling" .)