First institute in Persia designed by those with lots of hives (8)
I believe the answer is:
apiaries
'those with lots of hives' is the definition.
I can't judge whether this definition defines the answer.
'first institute in persia designed' is the wordplay.
'first' becomes 'a' (**).
'institute' becomes 'i' (common abbreviation as in MIT).
'in' is an insertion indicator.
'designed' indicates an anagram (designed with the letters).
'persia' with letters rearranged gives 'paries'.
'i' placed into 'paries' is 'piaries'.
'a'+'piaries'='APIARIES'
'by' acts as a link.
Can you help me to learn more?
(Other definitions for apiaries that I've seen before include "Places where bees are kept and nurtured" , "Bee houses" , "Strange sepia air for the Apis families" , "many buzzers!" , "Places where bee-hives are kept, honey farms" .)