Forgetfulness of men wandering in large continent (7)
I believe the answer is:
amnesia
'forgetfulness' is the definition.
(I've seen this before)
'men wandering in large continent' is the wordplay.
'wandering' indicates anagramming the letters.
'in' indicates putting letters inside.
'large continent' becomes 'asia' (I've seen this before).
'men' with letters rearranged gives 'mne'.
'mne' inserted within 'asia' is 'AMNESIA'.
'of' acts as a link.
(Other definitions for amnesia that I've seen before include "Elephants won't suffer such" , "Medical condition" , "As a mine (anag)" , "Main sea (anag.)" , "Am I sane? (anag)" .)