Friendless individual living initially in outskirts of Londonderry (6)
I believe the answer is:
lonely
'friendless' is the definition.
(thesaurus)
'individual living initially in outskirts of londonderry' is the wordplay.
'individual' becomes 'one'.
'initially' indicates taking the first letters.
'in' indicates putting letters inside.
'outskirts of' means to remove the middle letters.
'londonderry' with its middle removed is 'ly'.
The first letter of 'living' is 'l'.
'one'+'l'='onel'
'onel' placed inside 'ly' is 'LONELY'.
(Other definitions for lonely that I've seen before include "Forlorn, solitary" , "Lacking companions" , "Remote" , "In need of companionship" , "In want of company" .)