Given a hard time about, in that case (4)
I believe the answer is:
then
'in that case' is the definition.
('then' can be a synonym of 'in that case')
'given a hard time about' is the wordplay.
'given' becomes 'ne' (I am not sure about this - if you are sure you should believe this answer much more).
'a hard' becomes 'h'.
'time' becomes 't'.
'about' is a reversal indicator.
'ne'+'h'+'t'='neht'
'neht' reversed gives 'THEN'.
Can you help me to learn more?
(Other definitions for then that I've seen before include "soon?" , "Afterwards - as a result" , "Once upon a time" , "At that time; next" , "Consequently" .)