Good-natured female in a story (7)
I believe the answer is:
'good-natured' is the definition.
(I've seen this in another clue)
'female in a story' is the wordplay.
'female' becomes 'f' (common abbreviation).
'in' means one lot of letters goes inside another.
'story' becomes 'fable' (fable is a kind of story).
'f' put within 'afable' is 'AFFABLE'.
(Other definitions for affable that I've seen before include "Kind and friendly" , "Good-humoured, friendly" , "Congenial, easy to walk" , "Pleasant and friendly in manner" , "nice" .)