Having acquired knowledge about home working (2,2)
I believe the answer is:
in on
'having acquired knowledge' is the definition.
I know nothing about this answer so I cannot tell whether this works.
'home working' is the wordplay.
'home' becomes 'in' (to be in is to be (at) home).
'working' becomes 'on' (e.g. a machine is working or on).
'in'+'on'='IN ON'
'about' acts as a link.
Can you help me to learn more?
(Other definitions for in on that I've seen before include "Participating in - knowing about" , "Wise to" , "Aware of - being part of" , "Privy to" , "Aware of secret" .)