Home base accommodating students, primarily (5)
I believe the answer is:
roost
'home' is the definition.
(home for roosting birds)
'base accommodating students primarily' is the wordplay.
'base' becomes 'root' (synonyms).
'accommodating' is an insertion indicator.
'primarily' suggests taking the first letters.
The first letter of 'students' is 's'.
'root' going around 's' is 'ROOST'.
(Other definitions for roost that I've seen before include "Henhouse" , "Bat's resting place" , "Temporary resting-place" , "where fliers land" , "Bird's settling place" .)