In a so hospitable place is this bit of central London (4)
I believe the answer is:
soho
'central london' is the definition.
(area of London)
'in a so hospitable place is this bit' is the wordplay.
I cannot quite understand how this works, but
'so' could be 'soh' (synonyms) and 'soh' is present in the answer.
'bit' could be 'o' (resembles 0, a binary digit or bit) and 'o' is found within the answer.
This accounts for all the letters.
This explanation may well be incorrect...
'of' acts as a link.
Can you help me to learn more?
(Other definitions for soho that I've seen before include "District of London, noted for restaurants and nightclubs" , "Nightclub area in London" , "Colourful show-biz area of West End London" , "capital district" , "Smoke's part" .)