Instrument originally played in area near Oxford (5)

I believe the answer is:

piano

'instrument' is the definition.
(piano is a kind of instrument)

'originally played in area near oxford' is the wordplay.
'originally' suggests taking the first letters.
The first letters of 'played in area near oxford' is 'PIANO'.

(Other definitions for piano that I've seen before include "Musical instrument - play quietly" , "Soft - musical instrument" , "quiet passage" , "one of 6 [STEINWAYS]" , "Upright type?" .)

I've seen this clue in The Times.

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