Crossword Genius

Irritate with hypodermic (6)

Ross

I believe the answer is:

needle

I'm a little stuck... Click here to teach me more about this clue!

This clue might be a double definition.

'irritate' is the first definition.
(I've seen this before)

'hypodermic' is the second definition.
The definition and answer can be both man-made objects as well as being singular nouns.
Perhaps there's a link between them I don't understand?

'with' acts as a link.

Can you help me to learn more?

(Other definitions for needle that I've seen before include "Instrument to annoy" , "It's difficult to find one in a haystack" , "Annoy, tantalise" , "Thin pointer; antagonise" , "Implement for knitting and sewing" .)

I've seen this clue in The Mirror.
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