Crossword Genius

Killer mixed up a small portion (3,6)

Ross

I believe the answer is:

rat poison

'killer' is the definition.
(I've seen this before)

'mixed up a small portion' is the wordplay.
'mixed up' indicates anagramming the letters.
'small' becomes 's' (abbreviation - e.g. clothes size).
'a'+'s'+'portion'='asportion'
'asportion' anagrammed gives 'RAT-POISON'.

(Other definitions for rat poison that I've seen before include "Assistance in exterminating" , "Rodenticide" , "Vermin control" , "Vermin exterminator" , "eliminator of pests" .)

I've seen this clue in The Times.
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