Lack of honey — this is missing (6)
I believe the answer is:
dearth
'lack of' is the definition.
(I've seen this before)
'honey this is missing' is the wordplay.
'honey' becomes 'dear' (synonyms).
'missing' is a deletion indicator.
'this' with 'is' removed is 'th'.
'dear'+'th'='DEARTH'
(Other definitions for dearth that I've seen before include "Acute insufficiency" , "Red hat for scarcity" , "Severe lack" , "want" , "In short supply" .)