Leave after friend in Paris or friend in Madrid (5)
I believe the answer is:
amigo
'friend in madrid' is the definition.
(Spanish for friend)
'leave after friend in paris' is the wordplay.
'leave' becomes 'go' (to go is to depart or leave).
'after' means one lot of letters go next to another.
'friend in paris' becomes 'ami' (I've seen this in another clue).
'go' after 'ami' is 'AMIGO'.
'or' acts as a link.
(Other definitions for amigo that I've seen before include "Quixote's friend" , "buddy abroad?" , "Mate in Madrid?" , "Mexican friend" , "friend in Uruguay" .)