Leaves site to work around ten (5)
I believe the answer is:
exits
'leaves' is the definition.
('exit' can be a synonym of 'leave')
'site to work around ten' is the wordplay.
'to work' is an anagram indicator.
'around' indicates putting letters inside.
'ten' becomes 'x' ('X' can be a synonym of 'ten').
'site' is an anagram of 'eits'.
'eits' enclosing 'x' is 'EXITS'.
(Other definitions for exits that I've seen before include "Ways out" , "Goes out, leaves" , "Withdraws" , "Leaves the stage" , "Departs" .)