Like in Le Monde, new setter makes a start (12)
I believe the answer is:
Here is my best explanation:
'a start' is the definition.
('commencement' can be a synonym of 'start')
'like in le monde new setter' is the wordplay.
'like in le monde' becomes 'comme' ('like' in French eg in the newspaper Le Monde).
'new' becomes 'n'.
'setter' becomes 'cement' (something that sets).
'makes' is the link.