Live comfortably after heading for disaster (5)
I believe the answer is:
dwell
'live' is the definition.
(to live/dwell somewhere)
'comfortably after heading for disaster' is the wordplay.
'comfortably' becomes 'well' (synonyms).
'after' says to put letters next to each other.
'heading for' indicates taking the first letters.
The first letter of 'disaster' is 'd'.
'well' put after 'd' is 'DWELL'.
(Other definitions for dwell that I've seen before include "Reside - linger" , "Hang out" , "Lodge" , "Live (in a place)" , "Abide, reside" .)