Look after worker with short fat animal (7)
I believe the answer is:
Here is my best explanation:
'animal' is the definition.
The answer is an example.
'look after worker with short fat' is the subsidiary indication.
'look' becomes 'lo'.
'after' says to put letters next to each other.
'worker' becomes 'bee' (**).
'with' says to put letters next to each other.
'short' means to remove the last letter.
'fat' with its last letter taken off is 'fa'.
'lo' put after 'beefa' is 'beefalo'.
(Other definitions for beefalo that I've seen before include "Cross" and "cross".)