Lost men dad manipulated (6)
I believe the answer is:
damned
'lost' is the definition.
('damned' can be similar in meaning to 'lost')
'men dad manipulated' is the wordplay.
'manipulated' indicates anagramming the letters.
'men'+'dad'='mendad'
'mendad' anagrammed gives 'DAMNED'.
(Other definitions for damned that I've seen before include "Those condemned to eternal punishment" , "Abominable" , "Cursed" , "Consigned to hell or perdition" , "Condemned to Hell" .)