Crossword Genius

Main artery (5)

Ross

I believe the answer is:

aorta

'main artery' is the definition.
(largest artery)

This is the entire clue.

(Other definitions for aorta that I've seen before include "This carries blood from the heart" , "Bloody channel" , "Main artery of body" , "A rota (anag)" , "Great artery in body" .)

I've seen this clue in The Independent, The Sun, The Times, The Star Tribune, The Mirror and The New York Times.
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