Making comeback, survive wickedness (4)
I believe the answer is:
evil
'wickedness' is the definition.
(I know that wickedness can be written as evil)
'making comeback survive' is the wordplay.
'making comeback' says the letters should be written in reverse.
'survive' becomes 'live' (synonyms).
'live' backwards is 'EVIL'.
(Other definitions for evil that I've seen before include "very naughty" , "Wicked or immoral" , "Maleficent" , "Morally reprehensible" , "Wicked - social problem" .)