Mean home nurse (6)
I believe the answer is:
intend
'mean' is the definition.
('intend' can be a synonym of 'mean')
'home nurse' is the wordplay.
'home' becomes 'in' ('he's home' can mean 'he's in'**).
'nurse' becomes 'tend' (I've seen this before).
'in'+'tend'='INTEND'
(Other definitions for intend that I've seen before include "1 dn [DESIGN]" , "Aim, plan" , "Mean (to do something)" , "Have as one's plan" , "Plan, propose" .)