Meticulous from beginning to end, assuming nothing (8)
I believe the answer is:
thorough
'meticulous' is the definition.
(I've seen this before)
'from beginning to end assuming nothing' is the wordplay.
'from beginning to end' becomes 'through' (I've seen this before).
'assuming' is an insertion indicator (inserted letters are taken in or assumed).
'nothing' becomes 'O' (O resembles 0).
'through' placed around 'o' is 'THOROUGH'.
(Other definitions for thorough that I've seen before include "Complete - painstaking - unqualified" , "Assiduous, painstaking" , "Paying attention to detail, meticulous" , "Miticulous or exhaustive" , "Meticulous and conscientious" .)