Might one bite you in the nicest possible way? (6)

I believe the answer is:

insect

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'possible way?' is the definition.
Although both the answer and definition are singular nouns, I don't understand how they can define each other.

'might one bite you in the nicest' is the wordplay.
'nicest' anagrams to 'INSECT'.
But, I'm not clear how the anagram is indicated.

Can you help me to learn more?

(Other definitions for insect that I've seen before include "Entangle; open fabric" , "Cricket perhaps" , "Six-legged animal" , "Eg, bee, mosquito" , "Small, usually winged, creature" .)

I've seen this clue in the Evening Standard.

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