Note monarch from the east is no lone wolf (5)
I believe the answer is:
mixer
'no lone wolf' is the definition.
'note monarch from the east' is the wordplay.
'note' becomes 'mi' (as in 'do re mi'**).
'monarch' becomes 'rex' (I've seen this before).
'from the east' shows that the letters should be reversed in order.
'rex' reversed gives 'xer'.
'mi'+'xer'='MIXER'
'is' acts as a link.
(Other definitions for mixer that I've seen before include "Socialiser" , "Blender" , "Soft drink; type of tap" , "Drink to combine with alcohol" , "Device for cement or in kitchen" .)