Old can of talc thrown in a drawer with letter at the end (8)
I believe the answer is:
alcatraz
'old can' is the definition.
(historical prison)
'talc thrown in a drawer with letter at the end' is the wordplay.
'thrown' indicates anagramming the letters.
'in' means one lot of letters goes inside another.
'drawer' becomes 'ra' (Royal Academician, possibly an artist who 'draws').
'with' says to put letters next to each other.
'letter at the end' becomes 'z'.
'talc' is an anagram of 'lcat'.
'a'+'ra'='ara'
'lcat' placed into 'ara' is 'alcatra'.
'alcatra'+'z'='ALCATRAZ'
'of' acts as a link.
(Other definitions for alcatraz that I've seen before include "US island of a former maximum-security prison" , "Californian island" , "Once-notorious prison in San Francisco Bay" , "Old Calif. offshore prison" , "US island, formerly a famous prison" .)