Opens novel over the weekend it is said (6)
I believe the answer is:
Here is my best explanation:
'said' is the definition.
'opens novel over the weekend' is the subsidiary indication.
'novel' indicates an anagram.
'over' indicates putting letters inside.
'the weekend' becomes 'k' (I've seen this in other clues).
'opens' with letters rearranged gives 'spoen'.
'spoen' going around 'k' is 'spoken'.
'it is' is the link.
(Other definitions for spoken that I've seen before include "Voiced", "Uttered through the medium of speech", "Said", "Verbal", "Oral" and "Verbalised".)