People sailing to American or Mediterranean city (6)
I believe the answer is:
tarsus
'mediterranean city' is the definition.
'tarsus' can be an answer for 'city' (I have seen 'biblical city' mean 'tarsus' so perhaps 'city' could also mean 'tarsus'). I am not certain of the 'mediterranean' bit.
'people sailing to american' is the wordplay.
'people sailing' becomes 'tars' (I can't justify this - if you can you should give a lot more credence to this answer).
'to american' becomes 'US' (abbreviation for United States).
'tars'+'us'='TARSUS'
'or' acts as a link.
Can you help me to learn more?
(Other definitions for tarsus that I've seen before include "Bone" , "City of which St Paul was a native" , "Bones of the ankle and heel" , "Birthplace of St Paul" , "biblical city" .)