Port drinker gets up after ten drunk (8)
I believe the answer is:
entrepot
'port' is the definition.
(entrepot is a kind of port)
'drinker gets up after ten drunk' is the wordplay.
'drinker' becomes 'toper' (synonyms).
'gets up' says the letters should be written in reverse.
'after' means one lot of letters go next to another.
'drunk' indicates anagramming the letters.
'toper' back-to-front is 'repot'.
'ten' with letters rearranged gives 'ent'.
'repot' after 'ent' is 'ENTREPOT'.
(Other definitions for entrepot that I've seen before include "Trading port" , "Import/export warehouse, port" , "Storehouse" , "Bonded warehouse; port" .)