Port on the Loire (6)
I believe the answer is:
nantes
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">port on the loire</span>' is the definition.<br/ ><span class="explanation-format__explanation">(I've seen this before)</span><br/ ><br/ >This is all the clue.<br/ ></span>
(Other definitions for nantes that I've seen before include "A major French port" , "French football club" , "Ann set out for the French town" , "Loire city; its tolerant Edict" , "port abroad" .)