Professor Rowley's had a gut full of misery (6)
I believe the answer is:
sorrow
'misery' is the definition.
(I've seen this before)
'professor rowley's had' is the wordplay.
'had' indicates a hidden word (I've seen 'having' mean this).
'SORROW' is hidden within 'professor rowleys'.
'a gut full of' is the link.
I am not very happy about this link. Some or all of it may belong to another bit of the clue.
Can you help me to learn more?
(Other definitions for sorrow that I've seen before include "'One magpie for ..., two for joy (6)'" , "Sadness, feeling of regret" , "Unhappiness" , "Lamenting" , "Deep sadness" .)