Puffed up lot, a disaster in the cot (7)
I believe the answer is:
bloated
'puffed up' is the definition.
(thesaurus)
'lot a disaster in the cot' is the wordplay.
'disaster' indicates an anagram.
'in the' indicates putting letters inside.
'cot' becomes 'bed' (I've seen this in another clue).
'lot'+'a'='lota'
'lota' with letters rearranged gives 'loat'.
'loat' placed inside 'bed' is 'BLOATED'.
(Other definitions for bloated that I've seen before include "Swollen with gas, liquid or pride" , "Distended" , "Puffed out" , "Swollen with fluid/gas" , "Swollen with fluid or gas" .)