Queen comfortable, or nauseous? (6)
I believe the answer is:
queasy
'nauseous?' is the definition.
(thesaurus)
'queen comfortable' is the wordplay.
'queen' becomes 'qu'.
'comfortable' becomes 'easy' ('easy' can be similar in meaning to 'comfortable').
'qu'+'easy'='QUEASY'
'or' acts as a link.
(Other definitions for queasy that I've seen before include "Tender" , "Feeling slightly sick, maybe with indigestion" , "Unsettled" , "One released from marriage" , "Feeling slightly sick, maybe at sea" .)