Quiet house facing endless prejudice and fear (6)
I believe the answer is:
phobia
'fear' is the definition.
(phobia is a kind of anxiety disorder)
'quiet house facing endless prejudice' is the wordplay.
'quiet' becomes 'p' (music symbol for 'piano').
'house' becomes 'ho' (abbreviation for house).
'facing' means one lot of letters go next to another.
'endless' means to remove the last letter.
'prejudice' becomes 'bias' ('bias' can be a synonym of 'prejudice').
'bias' with its last letter removed is 'bia'.
'p'+'ho'+'bia'='PHOBIA'
'and' acts as a link.
(Other definitions for phobia that I've seen before include "Great fear of something" , "Irrational and lasting fear" , "Obsessive and persistent fear of something" , "Abnormal lasting fear or anxiety" , "Morbid, irrational fear" .)