Rabble-rousing second issue of book (8)
I believe the answer is:
sedition
'rabble-rousing' is the definition.
(both can mean encouraging rebellion)
'second issue of book' is the wordplay.
'second' becomes 's' (common abbreviation).
'issue of book' becomes 'edition' (one edition of a book).
's'+'edition'='SEDITION'
(Other definitions for sedition that I've seen before include "Offence against state" , "Criminal behaviour" , "Actions promoting disorder" , "revolt" , "that promotes rebellion" .)