Religious bigwigs take pills and ecstasy tabs (5)
I believe the answer is:
Here is my best explanation:
'religious bigwigs' is the definition.
The answer and definition can be both people as well as being plural nouns.
Maybe they are linked in a way I don't understand?
'take pills and ecstasy tabs' is the wordplay.
I cannot quite understand how this works, but
'ecstasy' could be 'e' (informal term for the drug) and 'e' is located in the answer.
The remaining letters 'pops' is a valid word which might be clued in a way I don't see.
This may be the basis of clue (or it may be nonsense).
(Other definitions for popes that I've seen before include "Heads of the Roman Catholic church" and "Pontiffs".)