Return it, angry and fed up (5)
I believe the answer is:
tired
'fed up' is the definition.
(thesaurus)
'return it angry' is the wordplay.
'return' shows that the letters should be reversed in order.
'angry' becomes 'red' (I've seen this in other clues).
'it' reversed gives 'ti'.
'ti'+'red'='TIRED'
'and' is the link.
(Other definitions for tired that I've seen before include "Played out" , "Sleepy" , "Weary or fed up" , "ready for bed" , "Depleted of energy" .)