Revolt as a result of undesirable uprising (5)
I believe the answer is:
repel
'revolt' is the definition.
('repel' can be a synonym of 'revolt')
'undesirable uprising' is the wordplay.
'undesirable' becomes 'leper' (I've seen this before).
'uprising' is a reversal indicator.
'leper' back-to-front is 'REPEL'.
'as a result of' acts as a link.
(Other definitions for repel that I've seen before include "Drive away or disgust" , "See off" , "Drive back or away" , "Drive back like leper" , "Nauseate" .)