Run away from anger and depression in Greece (5)
I believe the answer is:
Here is my best explanation:
'depression in greece' is the definition.
(the Vale of Tempe is a gorge in Greece)
'run away from anger' is the wordplay.
'run' becomes 'r' (cricket abbreviation).
'away from' is a deletion indicator.
'anger' becomes 'temper' (I've seen this before).
'temper' with 'r' removed is 'TEMPE'.
'and' acts as a link.
(Other definitions for tempe that I've seen before include "beauty spot", "beautiful valley", "valley of great beauty", "A beautiful place", "peaceful valley", "Grecian vale" and "Valley".)