Runaway given work by the Spanish Queen (6)
I believe the answer is:
eloper
'runaway' is the definition.
(I've seen this before)
'work by the spanish queen' is the wordplay.
'work' becomes 'op' (abbreviation for opus).
'by' says to put letters next to each other.
'the spanish' becomes 'el'.
'queen' becomes 'er' (abbreviation for Elizabeth Regina).
'op' put after 'el' is 'elop'.
'elop'+'er'='ELOPER'
'given' is the link.
(Other definitions for eloper that I've seen before include "One running away to get married" , "One keen to marry" , "One running off to marry" , "Lover escaping" , "Runaway 27 [SWEETHEART]" .)