Sadly mean to grasp silver and run (6)
I believe the answer is:
Here is my best explanation:
'run' is the definition.
(I've seen this before)
'sadly mean to grasp silver' is the subsidiary indication.
'sadly' indicates anagramming the letters.
'to grasp' is an insertion indicator.
'silver' becomes 'ag' ('Ag' can be a synonym of 'silver').
'mean' with letters rearranged gives 'mane'.
'mane' placed around 'ag' is 'manage'.
'and' is the link.
(Other definitions for manage that I've seen before include "Take responsibility for", "Handle, oversee", "Be in overall control of", "Control, direct, run", "Contrive", "Exercise control - don't fail", "Handle, run", "get on", "Cope" and "Organise".)