Settle after a fresh start in North America (12)
I believe the answer is:
newfoundland
'in north america' is the definition.
('Newfoundland' is part of 'north america')
'settle after a fresh start' is the wordplay.
'settle' becomes 'land'.
'after' is a charade indicator (letters next to each other).
'a fresh' becomes 'new' (I've seen this in another clue).
'start' becomes 'found' (I've seen this before).
'new'+'found'='newfound'
'land' after 'newfound' is 'NEWFOUNDLAND'.
(Other definitions for newfoundland that I've seen before include "Canadian province; breed of dog" , "Province of Canada" , "Island off Canada" , "Canadian isle and province" , "Canadian province and island" .)