Shut up and run! (4)
I believe the answer is:
bolt
I believe this is a double definition.
'shut up' is the first definition.
(thesaurus)
'run' is the second definition.
(I know that bolt is a more specific form of the action flee)
'and' acts as a link.
(Other definitions for bolt that I've seen before include "playwright" , "From the blue, it's a great surprise" , "Sprint? Yes he does!" , "Lightning flash, fasten" , "wolf" .)