Sign initially the union may fold (7)
I believe the answer is:
omentum
'fold' is the definition.
(a fold of peritoneum in the human body)
'sign initially the union may' is the wordplay.
'sign' becomes 'omen' (omen is a kind of sign**).
'initially' indicates taking the first letters.
The initial letters of 'the union may' is 'tum'.
'omen'+'tum'='OMENTUM'
(Another definition for omentum that I've seen is " Fold".)
I've seen this clue in The Independent.
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